Information about a laboratory test

Thyroglobulin (Tg): What Does This Blood Test Measure?

Measures the blood level of thyroglobulin, a protein produced by thyroid cells.

Test summary

Test name
Thyroglobulin (Tg)
Abbreviations
Tg
Category
Endocrinology / Thyroid Oncology
Panel
Thyroid Tumor Marker Monitoring
Specimen
Serum / plasma
Common units
ng/mL, µg/L

What does the test measure?

Measures the blood level of thyroglobulin, a protein produced by thyroid cells.

Why is the test ordered?

Used mainly for follow-up after treatment of differentiated thyroid cancer; it is not a general thyroid screening test.

Information about a low result

Low or undetectable thyroglobulin depends on the amount of remaining thyroid tissue, prior treatment, TSH, and other context.

Information about a high result

High or rising thyroglobulin may warrant further evaluation in post-treatment follow-up; a single value is not diagnostic by itself.

Reference and clinical context

Use the reference interval printed on your own laboratory report first. Hormone results may vary with the assay, age, sex, pregnancy, menstrual-cycle phase, and sampling time.

Reference ranges may vary by laboratory, method used, age, sex, pregnancy status, and clinical context. The reference range on your own laboratory report takes precedence.

Interpretation notes

Anti-Tg antibodies can make thyroglobulin appear falsely low. The same assay and preferably the same laboratory improve trend comparability.

Related specialties

  • Endocrinology
  • Nuclear Medicine
  • Medical Oncology
  • General Surgery

Frequently asked questions

Sources

  1. Thyroglobulin — U.S. National Library of Medicine (MedlinePlus)

    Government medical reference · 2026 · Thyroglobulin follow-up after thyroid-cancer treatment; method and anti-Tg interference · Verified: Aug 11, 2026