Can this result diagnose a condition on its own?

No. Laboratory results are interpreted with symptoms, medical history, sampling conditions, and related tests.

Which reference range or cutoff should I use?

Start with the performing laboratory's report and the purpose of testing; diagnostic cutoffs are separate sourced clinical thresholds.

When should I discuss the result with a healthcare professional?

Results that are clearly outside range, persistent, symptomatic, or unexpected should be reviewed by a healthcare professional.

Information about a laboratory test

Apolipoprotein A1: What Does This Test Measure?

Measures apolipoprotein A1, the main structural protein of HDL particles.

Test summary

Test name: Apolipoprotein A1
Abbreviations: ApoA1, ApoA-I
Category: Cardiometabolic / Advanced Lipids
Panel: Advanced Lipid / Cardiovascular Risk
Specimen: Serum
Common units: mg/dL, g/L

What does the test measure?

Measures apolipoprotein A1, the main structural protein of HDL particles.

Why is the test ordered?

Used in selected advanced lipid assessments, alongside HDL or as part of an ApoB/ApoA1 ratio.

Information about a low result

Low ApoA1 can be associated with lower HDL-related capacity and increased cardiovascular risk.

Information about a high result

High ApoA1 often accompanies higher HDL but does not by itself guarantee cardiovascular protection.

Reference and clinical context

Use the laboratory report as context, but treatment goals and risk thresholds vary with age, cardiovascular risk, diabetes, kidney disease, and current therapy.

Reference ranges may vary by laboratory, method used, age, sex, pregnancy status, and clinical context. The reference range on your own laboratory report takes precedence.

Interpretation notes

ApoA1 reference information can vary by sex and age and is often interpreted with ApoB.

Related specialties

Cardiology
Internal Medicine
Endocrinology
Family Medicine
Pediatric Cardiology

Frequently asked questions

More information about this test

Low Apolipoprotein A1: What Does It Mean?

Sources

Apolipoprotein B, Serum — Mayo Clinic Laboratories
Reference laboratory test catalog · 2026 · Age-specific ApoB categories and interpretation · Verified: Aug 12, 2026
Apolipoprotein A1, Serum — Mayo Clinic Laboratories
Reference laboratory test catalog · 2026 · Sex- and age-specific ApoA1 reference information and ApoB/ApoA1 context · Verified: Aug 12, 2026