Information about a laboratory test
A negative total anti-HBc result generally means core antibody was not detected; the rest of the panel still matters.
Total Anti-HBc checks total antibodies to the hepatitis B core antigen.
Total Anti-HBc is used with HBsAg and anti-HBs to understand past or current HBV exposure.
A negative total anti-HBc result generally means core antibody was not detected; the rest of the panel still matters.
A positive total anti-HBc can reflect past or current HBV exposure and does not by itself distinguish active from resolved infection.
Start with the performing laboratory's reference or decision range, assay method, specimen and reporting unit. A single result usually does not establish a diagnosis on its own.
Sourced reference/decision context for Total Anti-HBc
This is sourced reference or clinical-context information; the user's own laboratory report, assay method and clinical context take priority.
Reference ranges may vary by laboratory, method used, age, sex, pregnancy status, and clinical context. The reference range on your own laboratory report takes precedence.
Total anti-HBc is not produced by vaccination and should be interpreted with HBsAg and anti-HBs.
Clinical Testing and Diagnosis for Hepatitis B — Centers for Disease Control and Prevention
U.S. government clinical guidance · 2025 · HBsAg, anti-HBs, total anti-HBc triple-panel interpretation · Verified: Aug 12, 2026
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