No. The result should be interpreted with symptoms, medical history, assay method and related tests.
Information about a laboratory test
SHBG Low Result: What Does It Mean?
Low SHBG can change the relationship between total and free hormone levels and is not diagnostic by itself.
Test summary
- Test name
- SHBG
- Abbreviations
- SHBG
- Category
- Endocrinology / Reproductive
- Panel
- Androgen Evaluation
- Specimen
- Serum / plasma
- Common units
- nmol/L
What does the test measure?
SHBG measures sex hormone-binding globulin, a protein that binds hormones such as testosterone and estradiol.
Why is the test ordered?
SHBG is used to help contextualize androgen results such as total and free testosterone.
Information about a low result
Low SHBG can change the relationship between total and free hormone levels and is not diagnostic by itself.
Information about a high result
High SHBG can also alter the relationship between total and free hormones; the cause depends on clinical context.
Reference and clinical context
Start with the performing laboratory's reference or decision range, assay method, specimen and reporting unit. A single result usually does not establish a diagnosis on its own.
Reference ranges may vary by laboratory, method used, age, sex, pregnancy status, and clinical context. The reference range on your own laboratory report takes precedence.
Interpretation notes
SHBG is commonly interpreted with total testosterone and provides indirect context about testosterone availability.
Related specialties
- Endocrinology
- Internal Medicine
Frequently asked questions
Sources
Testosterone Levels Test — U.S. National Library of Medicine (MedlinePlus)
Government medical reference · 2025 · Total, free and bioavailable testosterone testing · Verified: Aug 12, 2026
SHBG Blood Test — U.S. National Library of Medicine (MedlinePlus)
Government medical reference · 2026 · SHBG and testosterone-binding context · Verified: Aug 12, 2026
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