Information about a laboratory test

Low Total Protein: What Does It Mean?

Low total protein can occur with reduced production, protein loss, inadequate nutrition or other systemic conditions.

Test summary

Test name
Total Protein
Abbreviations
TP, Total Serum Protein
Category
Hepatology / Serum Proteins
Panel
Liver Function Panel / Comprehensive Metabolic Panel
Specimen
Serum / plasma
Common units
g/dL, g/L

What does the test measure?

Measures the total amount of protein in blood, including albumin and globulins.

Why is the test ordered?

Used to help evaluate liver, kidney, nutritional and selected immune/protein-related conditions.

Information about a low result

Low total protein can occur with reduced production, protein loss, inadequate nutrition or other systemic conditions.

Information about a high result

High total protein may occur with dehydration or increased globulin/protein production.

Reference and clinical context

Start with the performing laboratory's reference interval, unit and specimen conditions. Numeric information on this page is stored as sourced example intervals or clinical thresholds.

Reference range 1

>= 6 – <= 8.3 g/dL

Population
Adults
Age range
18
Specimen
Serum / plasma

Example adult Total Protein reference interval

The source presents these values as a common example reference interval. Laboratory method, age and clinical context can change the range; the user's own report takes priority.

Reference ranges may vary by laboratory, method used, age, sex, pregnancy status, and clinical context. The reference range on your own laboratory report takes precedence.

Interpretation notes

Total protein should be considered with albumin; globulin fractions or protein electrophoresis may sometimes be needed.

Related specialties

  • Internal Medicine
  • Gastroenterology
  • Nephrology
  • Hematology

Frequently asked questions

Sources

  1. Liver Function Tests — U.S. National Library of Medicine (MedlinePlus)

    Government medical reference · 2026 · Liver panel components, purposes, pattern-based interpretation and limitations · Verified: Aug 12, 2026

  2. Comprehensive Metabolic Panel — U.S. National Library of Medicine (MedlinePlus)

    Government medical reference · 2026 · Example adult intervals for ALT, AST, ALP, albumin, bilirubin, total protein, BUN, creatinine and electrolytes · Verified: Aug 12, 2026

  3. Albumin Blood (Serum) Test — U.S. National Library of Medicine (MedlinePlus)

    Government medical reference · 2026 · Albumin meaning and adult example interval · Verified: Aug 12, 2026