Can this result diagnose a condition on its own?

No. The result should be interpreted with symptoms, medical history, assay method and related tests.

Which reference range should I use?

Use the performing laboratory's own reference or decision range and reporting method first.

When should I discuss the result with a healthcare professional?

Reactive/positive, clearly abnormal, persistent or symptom-associated results should be reviewed by a healthcare professional.

Information about a laboratory test

HOMA-IR What Does This Test Mean?

HOMA-IR is a calculated index derived from fasting glucose and fasting insulin to estimate insulin resistance.

Test summary

Test name: HOMA-IR
Abbreviations: HOMA-IR
Category: Glucose Metabolism / Endocrinology
Panel: Insulin Resistance Index
Specimen: Calculated from fasting blood tests
Common units: index

What does the test measure?

HOMA-IR is a calculated index derived from fasting glucose and fasting insulin to estimate insulin resistance.

Why is the test ordered?

HOMA-IR is used in research and selected clinical contexts to estimate insulin resistance from basal glucose and insulin.

Information about a low result

There is no single universal clinical 'low' cutoff for HOMA-IR.

Information about a high result

Higher HOMA-IR may be associated with greater insulin resistance in some populations, but there is no universal cutoff and method/population matter.

Reference and clinical context

Start with the performing laboratory's reference or decision range, assay method, specimen and reporting unit. A single result usually does not establish a diagnosis on its own.

Reference ranges may vary by laboratory, method used, age, sex, pregnancy status, and clinical context. The reference range on your own laboratory report takes precedence.

Interpretation notes

HOMA-IR is not a directly measured analyte; it is derived from fasting glucose and insulin. Cutoffs vary by population and methodology.

Related specialties

Endocrinology
Internal Medicine

Frequently asked questions

More information about this test

HOMA-IR High Result: What Does It Mean?

Sources

Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man — Matthews et al. / Diabetologia
Peer-reviewed original research · 1985 · Original HOMA method based on fasting glucose and insulin · Verified: Aug 12, 2026
Use and abuse of HOMA modeling — Wallace, Levy & Matthews
Peer-reviewed review · 2004 · HOMA methodology, interpretation limitations and appropriate use · Verified: Aug 12, 2026