Information about a laboratory test
High MMA can suggest vitamin B12 deficiency, but renal insufficiency and age can also raise MMA.
The Methylmalonic Acid test measures methylmalonic acid, a functional biomarker linked to vitamin B12-dependent metabolism.
Used as a functional supporting test when vitamin B12 deficiency is suspected, especially when serum B12 is borderline.
Low MMA is uncommon and generally not considered a health problem.
High MMA can suggest vitamin B12 deficiency, but renal insufficiency and age can also raise MMA.
Start with the performing laboratory's reference interval, unit, specimen type and method. Numeric information on this page is stored as sourced example intervals or clinical thresholds.
> 0.271 µmol/L
High MMA threshold that can support B12-deficiency assessment
This is a sourced clinical-context threshold and should not be used alone as a diagnosis or treatment decision. The laboratory report and clinical context take priority.
Reference ranges may vary by laboratory, method used, age, sex, pregnancy status, and clinical context. The reference range on your own laboratory report takes precedence.
MMA can be a more sensitive functional marker than serum B12; interpret it with B12, kidney function and, when relevant, homocysteine.
Vitamin B12 – Health Professional Fact Sheet — NIH Office of Dietary Supplements
U.S. government nutrition reference · 2025 · Vitamin B12 status, serum B12, MMA and homocysteine interpretation · Verified: Aug 12, 2026
Methylmalonic Acid (MMA) Test — U.S. National Library of Medicine (MedlinePlus)
Government medical reference · 2024 · MMA testing in vitamin B12 deficiency and meaning of high/low results · Verified: Aug 12, 2026
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