Low estradiol is expected after menopause; in reproductive-age people it can relate to ovarian or pituitary function, low body fat, or other causes.
Test summary
Test name
Estradiol (E2)
Abbreviations
E2
Category
Endocrinology / Reproductive
Panel
Reproductive Hormones
Specimen
Serum / plasma
Common units
pg/mL, pmol/L
What does the test measure?
Measures the blood level of estradiol, one of the main estrogens.
Why is the test ordered?
Used to evaluate ovarian function, fertility, menstrual disorders, menopause, puberty, and some hormone treatments.
Information about a low result
Low estradiol is expected after menopause; in reproductive-age people it can relate to ovarian or pituitary function, low body fat, or other causes.
Information about a high result
High estradiol may be physiologic depending on cycle phase or pregnancy; medicines and ovarian or adrenal factors can also affect it.
Reference and clinical context
Use the reference interval printed on your own laboratory report first. Hormone results may vary with the assay, age, sex, pregnancy, menstrual-cycle phase, and sampling time.
Reference range 1
>= 10 – <= 50 pg/mL
Population
Adults
Sex
Male
Specimen
Serum / plasma
Example reference interval
This is an example interval from the cited source. Menstrual-cycle phase, menopause, and pregnancy can materially affect reproductive-hormone results.
Reference range 2
>= 30 – <= 400 pg/mL
Population
Premenopausal adults
Sex
Female
Pregnancy status
No
Specimen
Serum / plasma
Example reference interval
This is an example interval from the cited source. Menstrual-cycle phase, menopause, and pregnancy can materially affect reproductive-hormone results.
Reference range 3
>= 0 – <= 30 pg/mL
Population
Postmenopausal adults
Sex
Female
Pregnancy status
No
Specimen
Serum / plasma
Example reference interval
This is an example interval from the cited source. Menstrual-cycle phase, menopause, and pregnancy can materially affect reproductive-hormone results.
Reference ranges may vary by laboratory, method used, age, sex, pregnancy status, and clinical context. The reference range on your own laboratory report takes precedence.
Interpretation notes
Age, menopausal status, and cycle timing are critical for estradiol interpretation in females. One adult-female interval cannot represent all phases.
Related specialties
Endocrinology
Obstetrics and Gynecology
Urology
Pediatric Endocrinology
Frequently asked questions
No. This result should be interpreted with related hormones, symptoms, and clinical context.
Use the reference interval provided by the laboratory that performed your test.
Results that are clearly outside range, persistent, or inconsistent with symptoms should be reviewed by a healthcare professional.