Information about a laboratory test
Negative/low anti-HBs alone does not define HBV infection status; vaccination history and other markers matter.
Anti-HBs measures antibody to hepatitis B surface antigen in blood.
Anti-HBs is used to assess immunity to hepatitis B, especially together with HBsAg and anti-HBc.
Negative/low anti-HBs alone does not define HBV infection status; vaccination history and other markers matter.
Positive anti-HBs can be consistent with immunity after vaccination or past infection; interpretation depends on the other HBV markers.
Start with the performing laboratory's reference or decision range, assay method, specimen and reporting unit. A single result usually does not establish a diagnosis on its own.
>= 10 mIU/mL
Sourced reference/decision context for Anti-HBs
This is sourced reference or clinical-context information; the user's own laboratory report, assay method and clinical context take priority.
Reference ranges may vary by laboratory, method used, age, sex, pregnancy status, and clinical context. The reference range on your own laboratory report takes precedence.
After a complete vaccine series, anti-HBs ≥10 mIU/mL is a known correlate of protection used by CDC; this threshold should not be applied without context.
Clinical Testing and Diagnosis for Hepatitis B — Centers for Disease Control and Prevention
U.S. government clinical guidance · 2025 · HBsAg, anti-HBs, total anti-HBc triple-panel interpretation · Verified: Aug 12, 2026
Screening and Testing for Hepatitis B Virus Infection: CDC Recommendations — United States, 2023 — Centers for Disease Control and Prevention
U.S. government recommendation · 2023 · HBV triple-panel screening and post-vaccination anti-HBs protection context · Verified: Aug 12, 2026
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